El ensayo se llevará a cabo para evaluar si BIBF 1120 en combinación con la terapia estándar con pemetrexed es más eficaz que el placebo (cápsula inactiva) más la terapia estándar con pemetrexed en pacientes con NSCLC en estadio IIIB, IV o recurrente. Se obtendrá información de seguridad sobre BIBF1120/pemetrexed.
starting dose of 200 mg bid taken daily except on the day of pemetrexed infusion . The dose can be reduced to 150 bid and then to 100 mg bid.
500 mg/metre squared administered as an intravenous infusion over 10 minutes on Day 1 of each 21 day cycle.
500 mg/metre squared administered as an intravenous infusion over 10 minutes on Day 1 of each 21 day cycle.
1000 ug IM injection starting a week before first pemetrexed infusion and every 9 weeks thereafter until discontinuation of pemetrexed
4 mg PO bid the day before, the day of and the day after each pemetrexed infusion
starting dose of 200 mg bid taken daily except on the day of pemetrexed infusion . The dose can be reduced to 150 bid and then to 100 mg bid.
4 mg PO bid the day before, the day of and the day after each pemetrexed infusion
1000 ug IM injection starting a week before first pemetrexed infusion and every 9 weeks thereafter until discontinuation of pemetrexed
400 ug once daily starting 1-2 weeks prior to the first dose of pemetrexed and continuing for at least 3 weeks after stopping pemetrexed.
1000 ug IM injection starting a week before first pemetrexed infusion and every 9 weeks thereafter until discontinuation of pemetrexed
4 mg PO bid the day before, the day of and the day after each pemetrexed infusion
400 ug once daily starting 1-2 weeks prior to the first dose of pemetrexed and continuing for at least 3 weeks after stopping pemetrexed.
starting dose of 200 mg bid taken daily except on the day of pemetrexed infusion . The dose can be reduced to 150 bid and then to 100 mg bid.
400 ug once daily starting 1-2 weeks prior to the first dose of pemetrexed and continuing for at least 3 weeks after stopping pemetrexed.
starting dose of 200 mg bid taken daily except on the day of pemetrexed infusion . The dose can be reduced to 150 bid and then to 100 mg bid.
500 mg/metre squared administered as an intravenous infusion over 10 minutes on Day 1 of each 21 day cycle.
Bs. As. Codigo Buenos Aires, Argentina
Córdoba, Argentina
Pergamino, Argentina
Quilmes Buenos Aires, Argentina
Rosario, Santa Fe, Argentina
San Miguel de Tucumán, Argentina