Resumen

El objetivo primario de este estudio es comparar la eficacia de tarlatamab con placebo evaluada mediante la supervivencia libre de progresión (SLP) basada en la revisión central independiente con enmascaramiento (RCIM) según los criterios de evaluación de respuesta en tumores sólidos v1.1 (RECIST 1.1) y en la prolongación de la supervivencia global (SG).

Elegibilidad

Edad mínima: 18 YearsSexo: ALL

Criterios de inclusión

Participant has provided informed consent prior to initiation of any study specific activities/procedures.
Age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years).
Histologically or cytologically confirmed small-cell lung cancer (SCLC).
Diagnosed and treated for LS-SCLC with concurrent chemotherapy and radiotherapy.
Has completed chemoradiotherapy without progression per RECIST 1.1 (ie, achieved complete response \[CR\], partial response \[PR\], or stable disease \[SD\]).
Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1.
Minimum life expectancy of 12 weeks.
Adequate organ function.
Toxicities attributed to concurrent chemoradiotherapy resolved to grade ≤ 1, unless otherwise specified. Excluding alopecia or fatigue.

Criterios de exclusión

Disease Related
Extensive-stage SCLC (ES-SCLC).
Any previous diagnosis of transformed non-small-cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) activating mutation positive NSCLC that has transformed to SCLC, or mixed SCLC NSCLC histology.
Evidence of interstitial lung disease or active, non-infectious pneumonitis. Other Medical Conditions
History of other malignancy within the past 2 years, with certain exceptions.
History of solid organ transplantation.
Myocardial infarction and/or symptomatic congestive heart failure (New York Heart Association \> class II) within 6 months prior to first dose of study treatment.
History of arterial thrombosis (eg, stroke or transient ischemic attack) within 6 months prior to first dose of study treatment.
Exclusion of human immunodeficiency virus (HIV) or active hepatitis infection based on criteria per protocol.
Participant with symptoms and/or clinical signs and/or radiographic signs that indicate an acute and/or uncontrolled active systemic infection within 7 days prior to the first dose of study treatment.
Prior/Concomitant Therapy
Received sequential chemotherapy and thoracic radiotherapy (no overlap of thoracic radiotherapy with chemotherapy) during chemoradiation.
Prior therapy with any selective inhibitor of the delta-like ligand 3 (DLL3) pathway.
Prior history of severe or life-threatening events from any immune-mediated therapy.
Receiving another anti-cancer therapy. Adjuvant hormonal therapy for resected breast cancer is permitted.
Receiving systemic corticosteroid therapy or any other form of immunosuppressive therapy within 7 days prior to enrollment.
Major surgical procedures within 28 days prior to first dose of study treatment.
Treatment with live virus, including live-attenuated vaccination, within 14 days prior to the first dose of study treatment. Inactive vaccines and live viral non-replicating vaccines within 3 days prior to first dose of study treatment.
Prior/Concurrent Clinical Study Experience
• Treatment in an alternative investigational trial within 28 days prior to enrollment.
Other Exclusions
Female participants of childbearing potential unwilling to use protocol specified method of contraception during treatment and for an additional 60 days after the last dose of study treatment.
Female participants who are breastfeeding or who plan to breastfeed while on study through 60 days after the last dose of study treatment.
Female participants planning to become pregnant or donate eggs while on study through 60 days after the last dose of study treatment.
Female participants of childbearing potential with a positive pregnancy test assessed at screening by a highly sensitive serum pregnancy test.
Male participants with a female partner of childbearing potential who are unwilling to practice sexual abstinence (refrain from heterosexual intercourse) or use contraception during treatment and for an additional 60 days after the last dose of study treatment.
Male participants with a pregnant partner who are unwilling to practice abstinence or use a condom during treatment and for an additional 60 days after the last dose of study treatment.
Male participants unwilling to abstain from donating sperm during treatment and for an additional 60 days after the last dose of study treatment.
Participant has known sensitivity to any of the products or components to be administered during dosing.
Participant likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the participant and investigator's knowledge.
History or evidence of any other clinically significant disorder, condition, or disease (with the exception of those outlined above) that, in the opinion of the investigator or Amgen physician, if consulted, would pose a risk to participant safety or interfere with the study evaluation, procedures or completion.

Ubicaciones

Fundacion Respirar

Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina

RECRUITING

Hospital Italiano de La Plata

La Plata, Buenos Aires, Argentina

RECRUITING

Hospital Universitario Austral

Pilar, Buenos Aires, Argentina

RECRUITING

Instituto Oncologico de Cordoba Ionc Fundacion Richardet Longo

Córdoba, Córdoba Province, Argentina

RECRUITING

Hospital Aleman Buenos Aires

CABA, Distrito Federal, Argentina

RECRUITING

Clinica Viedma

Viedma, Río Negro Province, Argentina

RECRUITING

Sanatorio 9 de Julio Cice 9 de Julio

San Miguel de Tucumán, Tucumán Province, Argentina

RECRUITING

Instituto Argentino de Diagnóstico y Tratamiento

Buenos Aires, Argentina

RECRUITING

Estudio de fase 3, aleatorizado, doble ciego, controlado con placebo y multicéntrico de la terapia con tarlatamab en sujetos con cáncer de pulmón de células pequeñas en estadio limitado (CPCP-EL) que no han progresado tras quimiorradioterapia concurrente

Resumen

Elegibilidad

Criterios de inclusión

Criterios de exclusión

Intervenciones

Tarlatamab

Placebo

Ubicaciones

Fundacion Respirar

Hospital Italiano de La Plata

Hospital Universitario Austral

Instituto Oncologico de Cordoba Ionc Fundacion Richardet Longo

Hospital Aleman Buenos Aires

Clinica Viedma

Sanatorio 9 de Julio Cice 9 de Julio

Instituto Argentino de Diagnóstico y Tratamiento

Patrocinadores

Contactos

Amgen Call Center