A Randomized, Open-Label, Phase 2 Study of Abemaciclib Plus Tamoxifen or Abemaciclib Alone, in Women With Previously Treated Hormone Receptor-Positive, HER2-Negative, Metastatic Breast Cancer

Activo, no reclutaFase 2ClinicalTrials.gov

ID: NCT02747004Tipo: INTERVENTIONALInicio: 14 de sept de 2016Fin estimado: 1 de dic de 2026

Traducción no disponible, mostrando original

Resumen

The main purpose of this study is to evaluate the safety and efficacy of abemaciclib plus tamoxifen or abemaciclib alone in women with previously treated hormone receptor-positive (HR+), human epidermal growth factor receptor 2 negative (HER2-), metastatic breast cancer.

Elegibilidad

Edad mínima: 18 YearsSexo: FEMALE

Criterios de inclusión

Have a diagnosis of HR+, HER2- breast cancer.
Relapsed or progressed following endocrine therapy.
Have received prior treatment with at least 2 chemotherapy regimens, of which at least 1 but no more than 2 have been administered in the metastatic setting.
Have the presence of measureable disease as defined by the Response Evaluation Criteria in Solid Tumors (RECIST 1.1).
Have a performance status ≤1 on the Eastern Cooperative Oncology Group (ECOG) scale.
Have discontinued previous therapies for cancer (including specifically, aromatase inhibitors, anti-estrogens, chemotherapy, radiotherapy, and immunotherapy) for at least 21 days for myelosuppressive agents or 14 days for nonmyelosuppressive agents prior to receiving study drug, and recovered from the acute effects of therapy (until the toxicity resolves to either baseline or at least Grade 1) except for residual alopecia or peripheral neuropathy.
Have adequate organ function.
Have negative serum pregnancy test within 7 days prior to the first dose of study treatment and agree to use highly effective precautions to prevent pregnancy during the study and for 3 weeks following last dose of study treatment.
Are able to swallow oral medication.

Criterios de exclusión

Have clinical evidence or history of central nervous system metastasis.
Have a personal history of any of the following conditions: syncope of either unexplained or cardiovascular etiology, ventricular tachycardia, ventricular fibrillation, or sudden cardiac arrest.
Have active bacterial or fungal infection (that is, requiring intravenous antibiotics at the time of initiating study treatment) and/or detectable viral infection.
Have received treatment with a prior cyclin-dependent kinase (CDK4) and CDK 6 inhibitor.
Have a preexisting chronic condition resulting in persistent diarrhea.
Have a history of any other cancer (except nonmelanoma skin cancer or carcinoma in-situ of the cervix or breast), unless in complete remission with no therapy for a minimum of 3 years.

Intervenciones

drug

Abemaciclib

Administered orally

drug

Tamoxifen

Administered orally

drug

Prophylactic Loperamide

Administered orally

Ubicaciones

CENIT Centro de Neurociencias, Investigación y Tratamiento

CABA, Buenos Aires, Argentina

Fundacion Ars Medica

San Salvador de Jujuy, Jujuy Province, Argentina

Clinica Viedma

Viedma, Río Negro Province, Argentina

Instituto de Oncología de Rosario

Rosario, Santa Fe Province, Argentina

Centro Para la Atención Integral del Paciente Oncologico (CAIPO)

San Miguel de Tucumán, Tucumán Province, Argentina

Sanatorio Parque

Salta, Argentina

Patrocinadores

PrincipalEli Lilly and Company

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