Resumen

The purpose of this study is to evaluate effectiveness of albendazole in the treatment of the asymptomatic infection with the parasite Toxocara in children. Treatment response is defined as a reduction in the number of eosinophils in blood. The study drug will be compared to placebo and randomly assigned in a double blind manner. Follow up will be prospective. 50 children (25 per group) will be enrolled in the study.

Elegibilidad

Edad mínima: 2 YearsEdad máxima: 15 YearsSexo: ALL

Criterios de inclusión

Pediatric ambulatory patients with asymptomatic toxocariasis
Children 2 - 15 years old
Absolute eosinophil count \> 1100 / mm3
Normal ophthalmoscopy

Criterios de exclusión

Treatment with a benzimidazole in the previous year
Infection by other nematodes (Ascaris lumbricoides, strongyloides stercoralis, uncinarias, Trichuris trichuria)
Symptomatic patients (prolonged fever, acute pneumonitis, hepatomegaly, splenomegaly, ocular compromise due to toxocara)
Concomitant diseases
Immunocompromised patients
Altered liver or kidney function
Pregnancy

Intervenciones

drug

Albendazole

Albendazole 10 - 15 mg/kg/day BID for 15 days

drug

Placebo

Placebo BID for 15 days

Ubicaciones

Parasitology Division, Children's Hospital "R Gutierrez" of Buenos Aires

Buenos Aires, Argentina

Patrocinadores

PrincipalHospital de Niños R. Gutierrez de Buenos Aires

Treatment of Asymptomatic Toxocariasis With Albendazole in Children. A Prospective, Randomized, Placebo-controlled Clinical Trial