Estudio de extensión multicéntrico, abierto, de un solo brazo, para evaluar la seguridad y tolerabilidad a largo plazo de inclisiran en participantes con hipercolesterolemia familiar heterocigótica u homocigótica que hayan completado los estudios adolescentes ORION-16 u ORION-13 (VICTORION-PEDS-OLE)

Criterios de inclusión

• Key inclusion:
• Male and female participants with a diagnosis of HeFH or HoFH who completed the ORION-16 or ORION-13 studies
• Per investigator's clinical judgment, participant derived benefit from treatment with inclisiran in the ORION-16 or ORION-13 studies
• Key exclusion:
• Participants who in the feeder inclisiran ORION-16 and ORION-13 studies either screen failed or permanently discontinued from the treatment/study for any reason or had serious safety or tolerability issues related to inclisiran treatment
• Any uncontrolled or serious disease, or any medical, physical, or surgical condition, that may either interfere with participation in the clinical study or interpretation of clinical study results, and/or put the participant at significant risk