The primary objective of this study is to evaluate the effect of brensocatib at 10 mg and 25 mg compared with placebo on the rate of pulmonary exacerbations (PEs) over the 52-week treatment period.

Elegibilidad

Edad mínima: 12 YearsEdad máxima: 85 YearsSexo: ALL

Criterios de inclusión

Provide their signed study informed consent to participate.
a. Adolescent participants must have signed study assent form to participate, and the adolescent's parent or legal guardian must have provided signed informed consent for the adolescent to participate.
Clinical history consistent with non-cystic fibrosis bronchiectasis (NCFBE) (cough, chronic sputum production and/or recurrent respiratory infections) that is confirmed by chest computerized tomography (CT) scan.
At least 2 PEs defined by need for antibiotic prescription by a physician for the signs and symptoms of respiratory infections in the past 12 months before the Screening Visit.
a. Adolescent participants are required to have at least 1 pulmonary exacerbation in the prior 12 months.
Women must be postmenopausal (defined as no menses for 12 months without an alternative medical cause), surgically sterile, or using highly effective contraception (ie, methods that can achieve a failure rate \<1% per year when used consistently and correctly) from Day 1 to at least 90 days after the last dose.
Male participants with female partners of childbearing potential must be using effective contraception from Day 1 to at least 90 days after the last dose.
Male participants with pregnant or non-pregnant women of child-bearing potential partners must use condoms to avoid potential exposure to the embryo/fetus.

Criterios de exclusión

A primary diagnosis of chronic obstructive pulmonary disease (COPD) or asthma as judged by the Investigator.
Bronchiectasis due to cystic fibrosis.
Current smokers as defined per Centers for Disease Control (CDC).
Known or suspected immunodeficiency disorder, including history of invasive opportunistic infections.
Known history of human immunodeficiency virus (HIV) infection.
Currently being treated for nontuberculous mycobacteria (NTM) lung infection, allergic bronchopulmonary aspergillosis, or tuberculosis (TB).
Active and current symptomatic infection by 2019 corona virus disease (COVID-19).
Inability to follow the procedures of the study (eg, due to language problems or psychological disorders).
Receiving medications or therapy that are prohibited as concomitant medications.
Previously participated in a clinical trial for brensocatib.
Received any live attenuated vaccine within 4 weeks prior to the first administration of brensocatib.
Suffering an exacerbation 4 weeks before Screening or during the Screening period.
Adult participants only: Have compliance issues with completion of electronic diary entries during the Screening Period and in the opinion of the Investigator, compliance is unlikely to improve during the study.
Participated in any other interventional clinical studies within 3 months before Screening Visit.
History of alcohol or drug abuse within 6 months prior to the Screening Visit.
Is the Investigator or any Sub-Investigator, research assistant, pharmacist, study coordinator, other staff or relative thereof directly involved in the conduct of the study.
Known history of hypersensitivity to brensocatib or any of its excipients.

Ubicaciones

ARG027

Bahía Blanca, Buenos Aires, Argentina

ARG021

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

ARG022

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

ARG002

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

ARG001

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

ARG003

Ciudad Autónoma de BuenosAires, Buenos Aires, Argentina

ARG004

Ciudad Autónoma de BuenosAires, Buenos Aires, Argentina

ARG006

La Plata, Buenos Aires, Argentina

ARG013

Mar del Plata, Buenos Aires, Argentina

ARG017

Mar del Plata, Buenos Aires, Argentina

ARG009

Villa Vatteone, Buenos Aires, Argentina

ARG012

Buenos Aires, Ciudad Autónoma de BuenosAires, Argentina

ARG018

Buenos Aires, Ciudad Autónoma de BuenosAires, Argentina

ARG026

Recoleta, Ciudad Autónoma de BuenosAires, Argentina

ARG023

Río Cuarto, Córdoba Province, Argentina

ARG014

Vistalba, Mendoza Province, Argentina

ARG010

Rosario, Santa Fe Province, Argentina

ARG015

San Miguel de Tucumán, Tucumán Province, Argentina

ARG025

San Miguel de Tucumán, Tucumán Province, Argentina

ARG005

Córdoba, Argentina

ARG007

Mendoza, Argentina

ARG011

Rosario, Argentina

ARG019

Santa Fe, Argentina

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy, Safety, and Tolerability of Brensocatib Administered Once Daily for 52 Weeks in Subjects With Non-Cystic Fibrosis Bronchiectasis - The ASPEN Study

Resumen

Elegibilidad

Criterios de inclusión

Criterios de exclusión

Intervenciones

Brensocatib 10 mg

Brensocatib 25 mg

Placebo

Ubicaciones

ARG027

ARG021

ARG022

ARG002

ARG001

ARG003

ARG004

ARG006

ARG013

ARG017

ARG009

ARG012

ARG018

ARG026

ARG023

ARG014

ARG010

ARG015

ARG025

ARG005

ARG007

ARG011

ARG019

Patrocinadores