Estudio de fase III, aleatorizado, multicéntrico, doble ciego para evaluar la eficacia, seguridad y tolerabilidad de zibotentan/dapagliflozina en comparación con dapagliflozina sola en participantes con enfermedad renal crónica y proteinuria elevada

Activo, no reclutaFase 3ClinicalTrials.gov

ID: NCT06087835Tipo: INTERVENTIONALInicio: 7 de nov de 2023Fin estimado: 18 de feb de 2027

Resumen

Este es un estudio de fase III, aleatorizado, multicéntrico y doble ciego para evaluar la eficacia, seguridad y tolerabilidad del tratamiento con zibotentan/dapagliflozina y dapagliflozina sola en participantes con enfermedad renal crónica (ERC) y proteinuria elevada.

Elegibilidad

Edad mínima: 18 YearsEdad máxima: 95 YearsSexo: ALL

Criterios de inclusión

Participant must be ≥ 18 years of age and of legal age of consent in the jurisdiction in which the study is taking place, at the time of signing the informed consent.
Diagnosis of CKD, defined as eGFR ≥ 20 and \< 90 mL/min/1.73 m2 and UACR \> 700 mg/g (\> 79 mg/mmol) or UPCR \> 1000 mg/g (\> 113 mg/mmoL).
All female participants must have a negative serum pregnancy test result at screening.
Female participants must be either
not of child-bearing potential or
women of child bearing potential (WOCBP) using at least one highly effective birth control method for at least 3 months prior to first dose of study intervention
Capable of giving signed informed consent
Provision of signed informed consent prior to any study specific procedure.
Provision of electronic informed consent prior to completion of the optional Study Participant Feedback Questionnaire (SPFQ).
Provision of signed and dated written Optional Genomics Initiative Research Information and Consent Form prior to collection of samples for optional genomics imitative research that supports the Genomic Initiative.
Receiving RAASi therapy (ACEi or ARB), and for the patient maximum tolerated labelled daily dose, that has been stable for at least 4 weeks.

Criterios de exclusión

Participants with NYHA class III or class IV Congestive HF at the time of enrolment.
Participants hospitalised for HF during the last 6 month prior to screening.
Evidence of rales or jugular venous distention on physical examination.
Participants with type 1 diabetes mellitus.
History of any life-threatening ventricular dysrhythmia (continuous or paroxysmal).
Blood pressure above 160 mmHg systolic.
Blood pressure below 90 mmHg systolic.
Participants hospitalised for heart disease or cardiac procedures or for COVID-19 during the last 3 months prior to screening.
History of solid organ transplantation or bone marrow transplant.
History or ongoing allergy/hypersensitivity, as judged by the Investigator, to SGLT2i therapy (eg, dapagliflozin, canagliflozin, empagliflozin or other SGLT2 inhibitors) or Endothelin Receptor Antagonists (eg, ambrisentan, atrasentan, bosentan, or other).
Any condition with a life expectancy of less than 2 years based on investigator´s clinical judgment.
Malignancy within the past 5 years. Exceptions to this criterion include non-melanoma skin cancer and curatively treated cervical carcinoma in situ.
Significant liver disease as judged by the investigator or severe hepatic impairment with AST or ALT \> 3 × ULN; or total bilirubin \> 2 × ULN at time of screening. An isolated increase in bilirubin in participants with known Gilbert's syndrome is not a reason for exclusion.
Known blood-borne diseases.
Clinically significant, unstable, or uncontrolled medical condition as assessed by the Investigator.
Participants on renal replacement therapy or previous kidney transplant.
Known history of drug or alcohol abuse within 12 months of screening.
Participants on treatment with strong or moderate CYP3A4 inducer.
Participants on systemic immunosuppression therapy other than stable maintenance therapy defined as prednisone 10 mg/day (or equivalent) or less, aziothioprine 100 mg/day or less; MMF 1000 mg/day or less for at least 3 months prior to Visit 1. Inhaled, nasal or dermatological steroids are also allowed.
Participants treated or expecting to be treated with tolvaptan, any other ERAs, or budesonide (where used to treat IBD or IgAN).
Participation in another clinical study with a study intervention administered in the last 3 months.

Intervenciones

drug

Zibotentan/Dapagliflozin

Participants will receive zibotentan/dapagliflozin in fixed-dose combination as per the arms they are randomized to

drug

Dapagliflozin

Participants will receive dapagliflozin as per the arms they are randomized to

Ubicaciones

Research Site

Ciudad de Buenos Aires, Argentina

Research Site

Ciudad de Buenos Aires, Argentina

Research Site

Mar del Plata, Argentina

Research Site

Mar del Plata, Argentina

Research Site

Santa Fe, Argentina

Patrocinadores

PrincipalAstraZeneca

Aviso: La información de este ensayo proviene de fuentes públicas y tiene carácter exclusivamente informativo. No constituye asesoramiento médico, regulatorio ni de ningún otro tipo. Las traducciones son automatizadas y no poseen validez oficial. Consultá siempre con un profesional de la salud. Ver Términos de Uso.

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