Resumen

Este estudio evaluará la eficacia y seguridad de niraparib en participantes con cáncer de mama HER2- con mutación tumoral en el gen BRCA (tBRCAmut) (independientemente del estado del receptor hormonal [RH], incluidos RH positivo [+] y TNBC) o TNBC de tipo salvaje tumoral BRCA (tBRCAwt) con enfermedad molecular basada en la presencia de ácido desoxirribonucleico tumoral circulante (ctDNA) tras la cirugía o la finalización de la terapia adyuvante.

Elegibilidad

Edad mínima: 18 YearsSexo: ALL

Criterios de inclusión

Stage I to III breast cancer with surgical resection of the primary tumor that is confirmed to be either: TNBC, irrespective of BRCA status or HR+/HER2- breast cancer with a known and documented deleterious or suspected deleterious tBRCA mutation.
Estrogen receptor (ER) and/or progesterone receptor (PgR) negativity is defined as immunohistochemistry (IHC) nuclear staining less than (\<) 1 percentage (%), or by Allred scoring system where TNBC is defined to be 0 out of 8 or 2 out of 8, or staining in \<1 % of cancer cells.
Completed prior standard therapy for curative intent.
Participants with HR+ breast cancer must be on a stable regimen of endocrine therapy.
Detectable ctDNA as measured by central testing.
An archival tumor tissue specimen of the primary tumor sufficient in quality and quantity for ctDNA assay design and tBRCA and Homologous recombination deficiency (HRD) testing is required.
An Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.

Criterios de exclusión

Prior treatment with a Poly Adenosine-diphosphate Ribose Polymerase (PARP) inhibitor.
Current treatment with a Cyclin-dependent kinase (CDK)4/6 inhibitor or endocrine therapy other than anastrozole, letrozole, exemestane, and tamoxifen with or without ovarian suppression.
Participants have any sign of metastasis or local recurrence after comprehensive assessment conducted per protocol.
Participants have shown no definitive response to preoperative chemotherapy by pathologic, radiographic or clinical evaluation, in cases where preoperative chemotherapy was administered.
Participants have inadequately treated or controlled hypertension.
Participants have received live vaccine within 30 days of planned start of study randomization.
Participants have a second primary malignancy.
Exceptions are the following: (a) Adequately treated non-melanoma skin cancer, curatively treated in situ cancer of the cervix, Ductal carcinoma in situ (DCIS) of the breast, Stage I Grade 1 endometrial carcinoma. (b) Other solid tumors and lymphomas (without bone marrow involvement) diagnosed \>=5 years prior to randomization and treated with no evidence of disease recurrence and for whom no more than 1 line of chemotherapy was applied.
Participant is pregnant, breastfeeding, or expecting to conceive children while receiving study treatment and/or for up to 180 days after the last dose of study treatment (except France).
Participant is immunocompromised. Participants with splenectomy are allowed. Participants with known human immunodeficiency virus (HIV) are allowed if they meet protocol-defined criteria.
Participants have a known history of myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML).

Ubicaciones

GSK Investigational Site

Buenos Aires, Argentina

GSK Investigational Site

Buenos Aires, Argentina

GSK Investigational Site

Buenos Aires, Argentina

GSK Investigational Site

Capital Federal, Argentina

GSK Investigational Site

Cipoletti Rio Negro, Argentina

GSK Investigational Site

Ciudad Autonoma Buenos Aires, Argentina

GSK Investigational Site

Ciudad AutOnoma de Buenos Aire, Argentina

GSK Investigational Site

Ciudad Autonoma de Buenos Aire, Argentina

GSK Investigational Site

Ciudad de Buenos Aires, Argentina

GSK Investigational Site

Entre Ríos, Argentina

Resumen

Elegibilidad

Criterios de inclusión

Criterios de exclusión

Intervenciones

Niraparib

Placebo

Ubicaciones

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

GSK Investigational Site

Patrocinadores