An International Multicentre Randomized Controlled Trial of Intensive Insulin Therapy Targeting Normoglycemia In Acute Myocardial Infarction: the RECREATE (REsearching Coronary REduction by Appropriately Targeting Euglycemia) Pilot Study

CompletadoFase 3ClinicalTrials.gov

ID: NCT00640991Tipo: INTERVENTIONALInicio: 1 de abr de 2008Fin estimado: 1 de jun de 2010

Traducción no disponible, mostrando original

Resumen

Insulin will safely reduce glucose levels in patients with acute ST-elevation myocardial infarction and admission hyperglycemia.

Descripción detallada

Patients will be randomly assigned to either the control arm and will receive usual AMI care or the experimental arm, which will include routine AMI care as well as intensive therapy intervention. In addition to the capillary blood glucose measurements obtained to titrate insulin doses in the experimental arm patients, laboratory plasma glucose will be drawn in all patients at randomization, 10, 24, 48, and 72 hours post randomization, 7 days post randomization (or hospital discharge if that occurs first), and 30 days post randomization.

Elegibilidad

Sexo: ALL

Criterios de inclusión

Both nondiabetic patients and patients with non-insulin-requiring type 2 diabetes mellitus admitted with a suspected AMI are eligible if they meet the following criteria:
Signs or symptoms of AMI with definite ECG changes, defined as persistent ST-segment elevation (\> or = than 1 mm)in two or more contiguous leads, or new left bundle branch block
Onset of symptoms within 24 hours before hospital presentation
Capillary blood glucose level on presentation \> or = 8.0 mmol/L (144 mg/dL)

Criterios de exclusión

Patient with conditions that REQUIRE the administration of insulin, including:
Type 1 diabetes mellitus, defined by a documented history of diabetes mellitus before the age of 30
Type 2 diabetes mellitus that was treated with insulin prior to AMI presentation
Type 2 diabetes mellitus that is known to be very poorly controlled (e.g. admission capillary blood glucose \> 16.0 mmol/L (288 mg/dL)or marked elevation in glucose for which the site investigator plans to treat with insulin therapy)
A history of severe hypoglycemic episodes (defined as hypoglycemia with symptoms which the patient is unable to reverse without the assistance of another person) within the past two years
Known or suspected end-stage liver disease (due to the risk of hypoglycemia in the setting of liver dysfunction and consequent impaired regulation of glucose homeostasis)
Cardiogenic shock on admission (due to the inaccuracy of glucose meter readings)
Documented pregnancy
Any concomitant disease (e.g. cancer) that might limit life expectancy to less than 90 days
Anticipated poor adherence with study treatments or an other factor that might jeopardize 90-day follow-up (e.g. no fixed address, long distance to hospital, etc.)
Prior enrollment in this trial or current enrollment in another trial of ST-segment elevation myocardial infarction

Intervenciones

drug

glulisine insulin, glargine insulin

IV infusion of glulisine, SC injection of glargine

Ubicaciones

Instituto Medico Adrogue

Adrogué, Buenos Aires, Argentina

Patrocinadores

PrincipalPopulation Health Research Institute

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