The purpose of this Proof of Concept (PoC) and Dose-finding (DF) basket study is to evaluate the efficacy and safety of orally administered Enpatoran over 24 weeks in systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE; subacute cutaneous lupus erythematosus \[SCLE\] and/or discoid lupus erythematosus \[DLE\]) participants in a randomized, double-blind, placebo-controlled, parallel, adaptive and dose-ranging setting. Study Duration: 33 weeks Visit Frequency: every 2 or 4 weeks Enpatoran is not available through an expanded access program.
Participants will receive film-coated tablets of Enpatoran at a low dose orally, twice daily (BID) up to 24 weeks.
Participants will receive film-coated tablets of Enpatoran at a medium dose, orally, BID up to 24 weeks.
Participants will receive film-coated tablets of Enpatoran at a high dose, orally, BID up to 24 weeks.
Participants will receive placebo matched to Enpatoran up to 24 weeks.
Buenos Aires, Argentina
Ciudad Autonoma Buenos Aires, Argentina
Ciudad Autonoma Buenos Aires, Argentina
Ciudad Autonoma Buenos Aires, Argentina
Mar del Plata, Argentina
Mendoza, Argentina
Rosario, Argentina
San Fernando, Argentina
San Juan, Argentina
San Miguel, Argentina
San Miguel de Tucumán, Argentina
San Miguel de Tucumán, Argentina