Resumen

Administration of Ticagrelor in patients with ST elevation myocardial infarction treated with pharmacological thrombolysis

Descripción detallada

Phase III, Randomized, International, Multicenter, Open label, with Blinded Adjudication of Outcomes, Non-Inferiority Clinical Trial to Explore the Safety and Efficacy of Ticagrelor Compared with Clopidogrel in Patients with Acute Coronary Syndrome with ST Elevation Treated with Pharmacological Thrombolysis.

Elegibilidad

Edad mínima: 18 YearsEdad máxima: 75 YearsSexo: ALL

Criterios de inclusión

Patients of both sexes aged ≥ 18 years and \< 75 years with ACS with ST segment elevation with onset during the previous 24 hours, documented by cardiac ischemic symptoms due to atherosclerosis of \> 10 minutes duration at rest, treated with pharmacological thrombolysis
Fibrinolytic therapy should be given to patients with STEMI and onset of ischemic symptoms within the previous 12 hours
Patients with acute coronary syndrome with ST segment elevation will be included provided they present ST segment elevation at the J point in two contiguous leads in electrocardiogram with cut-points: \> 0.1mV in all leads other than leads V2-V3, where the following cut points apply: \> 0.2 mV in men \> 40 years; \> 0.25 mV in men \< 40 years, or \>0.15 mV in women and at least 1 of the following criteria:
Angina-like chest pain or ischemic equivalent chest pain;
Abnormalities above the reference value for markers of myocardial necrosis (troponin and CK-MB).
The patient must be able to give informed consent in accordance with ICH GCP guidelines and local legislation and/or regulations.

Criterios de exclusión

Any contraindication against the use of clopidogrel (eg, hypersensitivity, moderate or severe liver disease, active bleeding or bleeding history, history of intracranial hemorrhage)
Need for oral anticoagulation therapy,
Concomitant oral or IV therapy with strong CYP3A inhibitors (ketoconazole, itraconazole, voriconazole, telithromycin, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir, grapefruit juice N1 L/d), CYP3A substrates with narrow therapeutic indices (cyclosporine, quinidine), or strong CYP3Ainducers (rifampin/rifampicin, phenytoin, carbamazepine)
Increased risk of bradycardia events
Dialysis required
Known clinically important thrombocytopenia
Known clinically important anemia
Any other condition that may put the patient at risk or influence study results in the investigators' opinion (eg, cardiogenic shock, severe hemodynamic instability, active cancer)
Participant in another investigational drug or device study within 30 d
Pregnancy or lactation
Any condition that increases the risk for noncompliance or being lost to follow-up
Involvement in the planning or conduct of the study
Previous enrollment or randomization in this study
Contraindications to fibrinolytic therapy including: 15
Any prior intracranial hemorrhage
Known structural cerebral vascular lesion (eg, Arterial Venous Malformation - AVM)
Known malignant intracranial neoplasm (primary or metastatic)
Ischemic stroke within 3 months
Suspected aortic dissection
Active bleeding or bleeding diathesis (excluding menses)
Significant closed head trauma or facial trauma within 3 months

Intervenciones

drug

Ticagrelor 180 mg

Ticagrelor, 180 mg as early as possible after the index event and not \>24 h post event followed by 90 mg twice daily for 12 months.

drug

Clopidogrel

300 mg clopidogrel as early as possible after the index event and not \> 24h post event, followed by 75mg/day for 12 months. For patients with \> 75 years the recommended load dose is 75 mg instead 300 mg.

Ubicaciones

Hospital Interzonal General de Agudos Dr, José Penna

Bahía Blanca, Argentina

Hospital Alvarez

Buenos Aires, Argentina

Hospital Español de La Plata

La Plata, Argentina

Sanatorio Modelo de Quilmes

Quilmes, Argentina

Hospital Del Cruce Nestor Kishner

San Juan Bautista, Argentina

Hospital Zenón Santillan

San Miguel de Tucumán, Argentina