The study aims at identifying the predictive markers after one month of Saizen therapy in Growth Hormone Deficiency (GHD) and Turner Syndrome children.

Elegibilidad

Edad mínima: 2 YearsEdad máxima: 16 YearsSexo: ALL

Criterios de inclusión

One of the following diagnoses and candidacy for SAIZEN® therapy:
A) GHD: documented pre-established diagnosis of GHD with a growth hormone (GH) peak response of \<10 microgram per liter (mcg/L) with 2 GH stimulation tests, without priming with oestradiol.
B) Turner syndrome: documented pre-established diagnosis by karyotype.
Prepubertal status according to Tanner Pre-established history of normal thyroid function or adequate substitution for at least 3 months.
Weight for stature within the population specific normal range (\>5th and \<95th percentiles) for gender Willingness and ability to comply with the protocol for the duration of the study.
Parent's or guardian's written informed consent, given before any study related procedure that is not part of the subject's normal medical care, with the understanding that the subject or parent/guardian may withdraw consent at any time without prejudice to future medical care. If the child is old enough to read and write, a separate assent form will be given.

Criterios de exclusión

Acquired GHD due to central nervous system tumour, trauma, infection, infiltration (documented by imaging), and history of irradiation or cranial surgery
Previous treatment with GH, growth hormone-releasing hormone (GHRH), anabolic steroids or any treatment affecting growth.
Previous treatment with corticosteroids, except in case of topical or inhaled corticosteroid administration for atopic disease. Corticosteroids for hormonal substitution are also allowed if the condition and the treatment regimen have been stable for at least 3 months.
Severe associated pathology affecting growth such as malnutrition, malabsorption, or bone dysplasia.
Chronic severe kidney disease.
Chronic severe liver disease.
Chronic infectious disease.
Acute or severe illness during the previous 6 months.
Significant concomitant illness that would interfere with participation or assessment in this study.
Active malignancy (except non-melanomatous skin malignancies that have undergone surgical excision and/or biopsy, diagnosis and treatment to resolution)
History or active Idiopathic intra-cranial hypertension (benign intracranial hypertension or pseudo-tumor cerebri).
Diabetes Mellitus type I \& II.
Any autoimmune disease.
Previous screening failure in this study.
Use of an investigational drug or participation in another clinical study within the last three months.

Intervenciones

drug

Saizen

Subjects with TS will receive SAIZEN® as subcutaneous injection at a dose of 0.050 milligram per kilogram (mg/kg) of body weight per day (within the recommended dosage 0.045-0.050 mg/kg body weight) for a period of 1 month

drug

Saizen

Subjects with GHD will receive SAIZEN® as subcutaneous injection at a dose of 0.035 mg/kg of body weight per day (within the recommended dosage 0.025-0.035 mg/kg body weight) for a period of 1 month.

A Phase IV Open-label Study of Predictive Markers in Growth Hormone Deficient and Turner Syndrome Pre-pubertal Children Treated With SAIZEN®

Resumen

Elegibilidad

Criterios de inclusión

Criterios de exclusión

Intervenciones

Saizen

Saizen

Ubicaciones

Local Medical Information Office

Patrocinadores