The study will evaluate the efficacy and safety of LCZ696 compared to enalapril on morbidity and mortality in patients with chronic heart failure (NYHA Class II - IV and EF =\< 35%).

Elegibilidad

Edad mínima: 18 YearsSexo: ALL

Criterios de inclusión

Patients must give written informed consent before any assessment is performed.
Outpatients ≥ 18 years of age, male or female.
Patients with a diagnosis of CHF NYHA class II-IV and reduced ejection fraction (EF =\< 35%) and elevated BNP.
Patients must be on an ACEI or an ARB at a stable dose of at least enalapril 10 mg/d or equivalent for at least 4 weeks.
Patients must be treated with a β-blocker, unless contraindicated or not tolerated, at a stable dose for at least 4 weeks.

Criterios de exclusión

Use of other investigational drugs at the time of enrollment, or within 30 days or 5 half-lives of enrollment, whichever is longer.
History of hypersensitivity or allergy to any of the study drugs, drugs of similar chemical classes, ACEIs, ARBs, or NEP inhibitors as well as known or suspected contraindications to the study drugs.
Previous history of intolerance to recommended target doses of ACEIs or ARBs
Known history of angioedema.
Requirement of treatment with both ACEIs and ARBs.
Current acute decompensated HF (exacerbation of chronic HF manifested by signs and symptoms that may require intravenous therapy).
Symptomatic hypotension and/or a SBP \< 100 mmHg.
Estimated GFR \< 30 mL/min/1.73m2 as measured by the simplified MDRD formula
Serum potassium \> 5.2 mmol/L.

Ubicaciones

Novartis Investigative Site

Buenos Aires, Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Buenos Aires, Argentina

Novartis Investigative Site

Buenos Aires, Buenos Aires, Argentina

Novartis Investigative Site

Caba, Buenos Aires, Argentina

Novartis Investigative Site

Caba, Buenos Aires, Argentina

Novartis Investigative Site

Ciudad Autonoma de Bs As, Buenos Aires, Argentina

Novartis Investigative Site

Lanús, Buenos Aires, Argentina

Novartis Investigative Site

Mar del Plata, Buenos Aires, Argentina

Novartis Investigative Site

Mar del Plata, Buenos Aires, Argentina

Novartis Investigative Site

Mar del Plata, Buenos Aires, Argentina

Novartis Investigative Site

Munro, Buenos Aires, Argentina

Novartis Investigative Site

Pilar, Buenos Aires, Argentina

Novartis Investigative Site

Quilmes, Buenos Aires, Argentina

Novartis Investigative Site

San Isidro, Buenos Aires, Argentina

Novartis Investigative Site

Zárate, Buenos Aires, Argentina

Novartis Investigative Site

Caba, Buenos Aires F.D., Argentina

Novartis Investigative Site

Caba, Buenos Aires F.D., Argentina

Novartis Investigative Site

Trelew, Chubut Province, Argentina

Novartis Investigative Site

Corrientes, Corrientes Province, Argentina