Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia

CompletadoClinicalTrials.gov

ID: NCT01346891Tipo: OBSERVATIONALInicio: 1 de jul de 2010

Traducción no disponible, mostrando original

Resumen

The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Descripción detallada

This is a Case Control study to compare the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Elegibilidad

Edad mínima: 21 YearsSexo: ALL

Criterios de inclusión

Patients older than 21 years, belonging to one of the following groups:
Patients who have had Thiazide induced hyponatremia with serum sodium lower than 125 meq/L included in the Institutional Registry of Hyponatremia (Cases)
Patients with good tolerance to chronic treatment with Thiazides tha never had associated hyponatremia (Controls)
Patients with normal serum sodium measurements before the start of the Thiazides

Criterios de exclusión

Refusal to participate or to the informed consent process
Unclear cause of hyponatremia, or other hyponatremia cause concomitant to Thiazide diuretics
Patients related to other individuals already included in the study

Ubicaciones

Hospital Italiano de Buenos Aires

Capital Federal, Buenos Aires F.D., Argentina

Patrocinadores

PrincipalHospital Italiano de Buenos Aires

ColaboradorSociedad Argentina de Hipertension Arterial (SAHA)

Aviso: La información de este ensayo proviene de fuentes públicas y tiene carácter exclusivamente informativo. No constituye asesoramiento médico, regulatorio ni de ningún otro tipo. Las traducciones son automatizadas y no poseen validez oficial. Consultá siempre con un profesional de la salud. Ver Términos de Uso.

Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and... | EligiMed