The purpose of this study is to determine if treatment with omecamtiv mecarbil when added to standard of care is well tolerated and superior to placebo in reducing the risk of cardiovascular death or heart failure events in adults with chronic heart failure with reduced ejection fraction (HFrEF).
This study was conducted by Amgen as the IND holder, with Cytokinetics as a collaborator. Due to the termination of the collaboration agreement between Amgen and Cytokinetics in May 2021 and subsequent transfer of the omecamtiv mecarbil IND from Amgen to Cytokinetics, Cytokinetics is now listed as the sponsor.
Omecamtiv mecarbil tablets for oral administration
Matching placebo tablets
Participants were required to be optimally managed with standard of care therapies for chronic HF (eg, beta blockers, renin angiotensin aldosterone system inhibitors), consistent with regional clinical practice guidelines, unless contraindicated.
Bahía Blanca, Buenos Aires, Argentina
CABA, Buenos Aires, Argentina
CABA, Buenos Aires, Argentina
CABA, Buenos Aires, Argentina
CABA, Buenos Aires, Argentina
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Coronel Suárez, Buenos Aires, Argentina
Mar del Plata, Buenos Aires, Argentina
Merlo, Buenos Aires, Argentina
Quilmes, Buenos Aires, Argentina
Quilmes, Buenos Aires, Argentina
Ramos Meija, Buenos Aires, Argentina
San Fernando, Buenos Aires, Argentina
San Isidro, Buenos Aires, Argentina
San Martín, Buenos Aires, Argentina
San Nicolás de los Arroyos, Buenos Aires, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
Córdoba, Córdoba Province, Argentina
Villa María, Córdoba Province, Argentina
Santa Rosa, La Pampa Province, Argentina
Rosario, Santa Fe Province, Argentina
Rosario, Santa Fe Province, Argentina
Venado Tuerto, Santa Fe Province, Argentina
San Miguel de Tucumán, Tucumán Province, Argentina
San Miguel de Tucumán, Tucumán Province, Argentina
Buenos Aires, Argentina
Corrientes, Argentina
Corrientes, Argentina
Córdoba, Argentina
Córdoba, Argentina
Córdoba, Argentina
Salta, Argentina
Santa Fe, Argentina