Use of Ramipril and Felodipine Combination Therapy in Hypertension: An Effectiveness Study With Local Patients in Argentina

CompletadoFase 4ClinicalTrials.gov

ID: NCT00507845Tipo: INTERVENTIONALInicio: 1 de jun de 2007

Traducción no disponible, mostrando original

Resumen

Primary: * To assess effectiveness of Ramipril-Felodipine in hypertensive Argentinean patients Secondary: * To assess tolerability of Ramipril-Felodipine in hypertensive Argentinean patients.

Elegibilidad

Edad mínima: 21 YearsSexo: ALL

Criterios de inclusión

Outpatient
Patients who couldn´t control their hypertension after 6 weeks of treatment with monotherapy (calcium blockers, beta blockers, diuretics, ACE inhibitors, AT2 blockers)(uncontrolled hypertension).

Criterios de exclusión

Already on fixed-dose combination treatment for hypertension
Contraindication to angiotensin converting enzyme (ACE) inhibitors or CCB therapy
Known hypersensitivity to felodipine (or other dihydropyridines), ramipril, other ACE or any of the excipients of ramipril felodipine.
History of angioedema
Unstable haemodynamic conditions: cardiovascular shock, untreated heart failure, acute myocardial infarction, unstable angina pectoris, stroke.
Patients with AV block II or III
Severely impaired hepatic function.
Pre-existing bilateral renal artery stenosis or stenosis of the artery to a solitary kidney
Pregnant and lactating mothers
Patients on dialysis or haemofiltration.
Patients with creatinine clearance \< 20ml/min
Use of potassium sparing diuretics
Severe hypertension (SBP ≥ 180 mmhg or DBP ≥ 110 mmhg)
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.

Intervenciones

drug

Ramipril-Felodipine

Ramipril + felodipine 2.5/2.5mg per tablet. One tablet to be taken Od for 8 weeks (this dose could be increased at week 2 to 4 to 5 mg daily because of uncontrolled hypertension).

Ubicaciones

Sanofi-aventis administrative office

Buenos Aires, Argentina

Patrocinadores

PrincipalSanofi

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