Ensayo aleatorizado, doble ciego, doble simulación, controlado con placebo, con diseño factorial 4x4 para evaluar comprimidos de telmisartán 20, 40 y 80 mg en combinación con cápsulas de amlodipina 2,5, 5 y 10 mg después de ocho semanas de tratamiento en pacientes con hipertensión estadio I o II, con un subestudio de MAPA

Criterios de exclusión

• Patient is pregnant; breast-feeding; unwilling to use birth control during the study; has secondary hypertension; severe renal dysfunction; hepatic insufficiency; stroke within the last six months; myocardial infarction, cardiac surgery, percutaneous transluminal coronary angioplasty, unstable angina or coronary artery bypass graft within the past three months; unstable or uncontrolled diabetes for the past three months defined as a glucosylates hemoglobin (HbA1c) greater than ten percent ; history of angioedema or hypersensitivity related to either study drug.
• Systolic Blood Pressure (SBP) is greater than or equal to 180 millimeters of mercury (mmHg), Diastolic Blood Pressure (DBP) is greater than or equal to 110 mmHg.