Primary Objective: To evaluate the efficacy of the association Lantus (once-a-day, od) Apidra (thrice-a-day, tid) in terms of change HbA1c from baseline to end of study (week 24), in patients with Type 1 Diabetes Mellitus (T1DM). Secondary Objectives: To evaluate: * The change of hemoglobin A1c (HbA1c) from baseline to week 12 * The percentage of patients with HbA1c \< 7% at week 12 and week 24 * The FBG and the 7-point self monitoring of blood glucose (SMBG) at baseline, week 12 and week 24 * The daily dose for both insulin glulisine insulin glargine at baseline, week 12 and week 24 * The incidence of symptomatic hypoglycemias * Adverse events
After a two-week run-in period patients will enter a six-month treatment period. Estimated study duration per patient : 26 weeks (including a 2-week run-in period).
Pharmaceutical form: solution for injection Route of administration: sub-cutaneous Dose regimen: once a day at bedtime
Pharmaceutical form: solution for injection Route of administration: sub-cutaneous Dose regimen: three times a day, preferably just before the meal
Caba, Argentina
Caba, Argentina
Caba, Argentina
Caba, Argentina
Morón, Argentina