Resumen

Este es un estudio multicéntrico grande para examinar si la ingesta perioperatoria de ácidos grasos poliinsaturados n-3 (AGPI) reducirá la aparición de fibrilación o aleteo auricular (FA) posoperatorio en pacientes sometidos a cirugía cardíaca (CC).

Elegibilidad

Edad mínima: 18 YearsSexo: ALL

Criterios de inclusión

Age 18 years or over
Scheduled for CS on the following day or later, including coronary artery bypass, valve surgery, any other open cardiac surgery (i.e., that includes opening of the pericardium), or any combination.
Sinus rhythm on current ECG (sinus bradycardia, sinus tachycardia, and ectopy are acceptable).

Criterios de exclusión

Regular use (3 or more days/week) of fish oil within the past 4 weeks.
Known allergy or intolerance to fish oil or corn oil.
Currently pregnant.
Unable to provide informed written consent.
Current or planned cardiac transplant or LVAD

Intervenciones

drug

Omega -3 fatty acids

10g dose of oral omega-3 fatty acid capsules over 3-5 days before surgery (or 8 g over 2 days before surgery), including the morning of surgery, followed by 2g/d after surgery for 10 days, or until discharge, whichever occurs first.

drug

Placebo

Olive Oil capsules

Patrocinadores

PrincipalBrigham and Women's Hospital

ColaboradorThe OPERA Investigators

(OPERA) Ensayo clínico aleatorizado para examinar si la ingesta perioperatoria de ácidos grasos poliinsaturados n-3 reducirá la aparición de fibrilación auricular posoperatoria en pacientes sometidos a cirugía cardíaca